typically include altered thoughts, feelings, and equally important awareness of one’s surroundings. Similarly Many users have visual or auditory hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical.
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Lsd. Lysergic acid diethylamide, also known colloquially as acid, is a hallucinogenic drug. LSD does not appear to be addictive, in the same way Its frequent use can cause acute tolerance, requiring much larger doses to feel an effect. Adverse psychiatric reactions are possible, such as anxiety, paranoia, and delusions, furthermore Distressing flashbacks might occur in spite of no further use, a condition called hallucinogen persisting perception disorder.
Effects of LSD;
Effects typically include altered thoughts, feelings, and equally important awareness of one’s surroundings. Similarly Many users have visual or auditory hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical.
LSD was first made by Albert Hofmann in 1938 from lysergic acid, a chemical derived from ERGOT, a fungus that grows on rye and other grains. Hofmann discovered its hallucinogenic properties in 1943. In the 1950s, the central intelligence agency(CIA) believed that the drug might be useful for mid control, so they tested it on people, some without their knowledge, in a program called MKUltra. LSD was sold as a medication for research purposes under the trade-name Delysid in the 1950s and 1960s. In November 2020, a referendum determined that it would be decriminalize in the US state of orogen.
Reactivity and degradation
“LSD,” writes the chemist Alexander Shulgin, “is an unusually fragile molecule … As a salt, in water, cold, and free from air and light exposure, it is stable indefinitely.
LSD has two labile protons at the tertiary stereogenic C5 and C8 positions, rendering these centers prone to epimerisation. The C8 proton is more labile due to the electron-withdrawing carboxamide attachment, but removal of the chiral proton at the C5 position (which was once also an alpha proton of the parent molecule tryptophan) is assisted by the inductively withdrawing nitrogen and pi electron delocalisation with the indole ring.
LSD also has enamine-type reactivity because of the electron-donating effects of the indole ring. Because of this, chlorine destroys LSD molecules on contact; even though chlorinated tap water contains only a slight amount of chlorine, the small quantity of compound typical to an LSD solution will likely be eliminated when dissolved in tap water. The double bond between the 8-position and the aromatic ring, being conjugated with the indole ring, is susceptible to nucleophilic attacks by water or alcohol, especially in the presence of UV or other kinds of light.
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